Journal
FRONTIERS IN PHYSIOLOGY
Volume 6, Issue -, Pages -Publisher
FRONTIERS RESEARCH FOUNDATION
DOI: 10.3389/fphys.2015.00107
Keywords
heart; development; myocardial infarction; macrophages; yolk sac; hematopoiesis; inflammation
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Funding
- DZHK (German Centre for Cardiovascular Research)
- BMBF (German Ministry of Education and Research)
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Ischemic heart disease is a common condition and a leading cause of mortality and morbidity. Macrophages, besides their role in host defense and tissue homeostasis, are critical players in the pathophysiological processes induced by myocardial infarction. In this article we will summarize the current understanding of the role of monocytes and macrophages in myocardial damage and cardiac remodeling in relation to their origin and developmental paths. Furthermore, we describe their potential implications in therapeutic strategies to modulate myocardial healing and regeneration.
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