Journal
FRONTIERS IN PHARMACOLOGY
Volume 6, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2015.00279
Keywords
integrins; hallmarks of cancer; proliferation; migrationinvasion; resistance to cell death; angiogenesis; therapeutic target
Categories
Funding
- Ligue Contre le Cancer (Comite du Grand Est)
- Fondation ARC pour le Recherche stir le Cancer
- Canceropole Grand Est
- Region Alsace
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Integrins belong to a large family of alpha beta heterodimeric transmembrane proteins first recognized as adhesion molecules that bind to dedicated elements of the extracellular matrix and also to other surrounding cells. As important sensors of the cell microenvironment, they regulate numerous signaling pathways in response to structural variations of the extracellular matrix. Biochemical and biomechanical cues provided by this matrix and transmitted to cells via integrins are critically modified in tumoral settings. lntegrins repertoire are subjected to expression level modifications, in tumor cells, and in surrounding cancer-associated cells, implicated in tumor initiation and progression as well. As critical players in numerous cancer hallmarks, defined by Hanahan and Weinberg (2011), integrins represent pertinent therapeutic targets. We will briefly summarize here our current knowledge about integrin implications in those different hallmarks focusing primarily on beta 1 integrins.
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