4.7 Article

Identifying problematic drugs based on the characteristics of their targets

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Large-scale prediction and testing of drug activity on side-effect targets

Eugen Lounkine et al.

NATURE (2012)

Article Biotechnology & Applied Microbiology

Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing

Timothy A. Whitehead et al.

NATURE BIOTECHNOLOGY (2012)

Article Biotechnology & Applied Microbiology

Diagnosing the decline in pharmaceutical R&D efficiency

Jack W. Scannell et al.

NATURE REVIEWS DRUG DISCOVERY (2012)

Review Endocrinology & Metabolism

Metabolic and cardiovascular adverse effects associated with antipsychotic drugs

Marc De Hert et al.

NATURE REVIEWS ENDOCRINOLOGY (2012)

Article Biochemistry & Molecular Biology

Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery

Feng Zhu et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Biochemistry & Molecular Biology

ChEMBL: a large-scale bioactivity database for drug discovery

Anna Gaulton et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Multidisciplinary Sciences

HIPPIE: Integrating Protein Interaction Networks with Experiment Based Quality Scores

Martin H. Schaefer et al.

PLOS ONE (2012)

Article Biochemistry & Molecular Biology

Getting pharmaceutical R&D back on target

Mark E. Bunnage

NATURE CHEMICAL BIOLOGY (2011)

Article Multidisciplinary Sciences

Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin

Sarel J. Fleishman et al.

SCIENCE (2011)

Review Biochemistry & Molecular Biology

Antipsychotic drugs and obesity

Christoph U. Correll et al.

TRENDS IN MOLECULAR MEDICINE (2011)

Article Computer Science, Interdisciplinary Applications

A similarity network approach for the analysis and comparison of protein sequence/structure sets

Ioannis Valavanis et al.

JOURNAL OF BIOMEDICAL INFORMATICS (2010)

Article Biochemistry & Molecular Biology

A side effect resource to capture phenotypic effects of drugs

Michael Kuhn et al.

MOLECULAR SYSTEMS BIOLOGY (2010)

Article Biochemistry & Molecular Biology

SIMAP-a comprehensive database of pre-calculated protein sequence similarities, domains, annotations and clusters

Thomas Rattei et al.

NUCLEIC ACIDS RESEARCH (2010)

Article Biochemical Research Methods

BLAST plus : architecture and applications

Christiam Camacho et al.

BMC BIOINFORMATICS (2009)

Article Multidisciplinary Sciences

Predicting new molecular targets for known drugs

Michael J. Keiser et al.

NATURE (2009)

Article Biochemical Research Methods

An empirical framework for binary interactome mapping

Kavitha Venkatesan et al.

NATURE METHODS (2009)

News Item Biotechnology & Applied Microbiology

Portfolio analysis and R&D decision making

Richard Evans et al.

NATURE REVIEWS DRUG DISCOVERY (2009)

Article Biotechnology & Applied Microbiology

Lessons from 60 years of pharmaceutical innovation

Bernard Munos

NATURE REVIEWS DRUG DISCOVERY (2009)

Review Clinical Neurology

Benzodiazepines in epilepsy: pharmacology and pharmacokinetics

J. Riss et al.

ACTA NEUROLOGICA SCANDINAVICA (2008)

Article Biochemical Research Methods

Prediction of drug-target interaction networks from the integration of chemical and genomic spaces

Yoshihiro Yamanishi et al.

BIOINFORMATICS (2008)

Article Biochemistry & Molecular Biology

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

Beth Apsel et al.

NATURE CHEMICAL BIOLOGY (2008)

Review Biochemistry & Molecular Biology

Network pharmacology: the next paradigm in drug discovery

Andrew L. Hopkins

NATURE CHEMICAL BIOLOGY (2008)

Article Multidisciplinary Sciences

Drug target identification using side-effect similarity

Monica Campillos et al.

SCIENCE (2008)

Article Pharmacology & Pharmacy

The Molecular Basis of Class Side Effects Due to Treatment with Inhibitors of the VEGF/VEGFR Pathway

Jeanine M. Roodhart et al.

CURRENT CLINICAL PHARMACOLOGY (2008)

Article Biotechnology & Applied Microbiology

Drug-target network

Muhammed A. Yildirim et al.

NATURE BIOTECHNOLOGY (2007)

Article Biotechnology & Applied Microbiology

Relating protein pharmacology by ligand chemistry

Michael J. Keiser et al.

NATURE BIOTECHNOLOGY (2007)

Article Computer Science, Artificial Intelligence

Rotation forest:: A new classifier ensemble method

Juan J. Rodriguez et al.

IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE (2006)

Article Biochemical Research Methods

Integrating multi-attribute similarity networks for robust representation of the protein space

Orhan Çamoglu et al.

BIOINFORMATICS (2006)

Article Biochemistry & Molecular Biology

Similarity networks of protein binding sites

ZD Zhang et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2006)

Article Biochemistry & Molecular Biology

DrugBank: a comprehensive resource for in silico drug discovery and exploration

David S. Wishart et al.

NUCLEIC ACIDS RESEARCH (2006)

Article Biochemical Research Methods

ROCR: visualizing classifier performance in R

T Sing et al.

BIOINFORMATICS (2005)

Article Multidisciplinary Sciences

Protein ranking: From local to global structure in the protein similarity network

J Weston et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Sociology

Structural holes and good ideas

RS Burt

AMERICAN JOURNAL OF SOCIOLOGY (2004)

Article Biochemical Research Methods

Data mining in bioinformatics using Weka

E Frank et al.

BIOINFORMATICS (2004)

Article Computer Science, Artificial Intelligence

Random forests

L Breiman

MACHINE LEARNING (2001)

Review Pharmacology & Pharmacy

Mechanism of action in thalidomide teratogenesis

TD Stephens et al.

BIOCHEMICAL PHARMACOLOGY (2000)