Journal
FRONTIERS IN NEUROSCIENCE
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2015.00198
Keywords
spinal muscular atrophy (SMA); amyotrophic lateral sclerosis (ALS); huntington's disease (HD); parkinson's disease (PD); alzheimer disease (AD); multiple sclerosis (MS); neuroinflammation; microglia
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Funding
- German Muscular Foundation (Deutsche Muskelstiftung)
- Deutsche Gesellschaft fur Muskelkranke (DGM)
- Initiative SMA of the Gesellschaft fur Muskelkranke (DGM)
- Niedersachsen-Research Network on Neuroinfectiology (N-RENNT) of the Ministry of Science and Culture of Lower Saxony
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ROCK inhibition has been largely applied as a strategy to treat neurodegenerative diseases (NDDs) and promising results have been obtained in the recent years. However, the underlying molecular and cellular mechanisms are not fully understood and different models have been proposed for neurodegenerative disorders. Here, we aim to review the current knowledge obtained for NDDs identifying common mechanisms as well as disease-specific models. In addition to the role of ROCK in different cell types such as neurons and microglia, we focus on the molecular signaling-pathways which mediate the beneficial effects of ROCK. Besides canonical ROCK signaling, modulation of neighboring pathways by non-canonical ROCK-crosstalk is a recurrent pattern in many NDD-model systems and has been suggested to mediate beneficial effects of ROCK-inhibition.
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