Journal
FRONTIERS IN NEUROSCIENCE
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2015.00108
Keywords
leptin; leptin receptors; insulin; diabetes mellitus; diabetes mellitus type 1; diabetes mellitus type 2; central nervous system
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Funding
- American Heart Association (Scientist Development Grant) [14SDG17950008]
- European Commission (Marie Curie Career Integration) [320898]
- European Commission (ERC-Consolidator Grant) [614847]
- Swiss National Science Foundation [310030_146533/1]
- Louis-Jeantet Foundation
- Gertrude von Meissner Foundation
- Swiss National Science Foundation (SNF) [310030_146533] Funding Source: Swiss National Science Foundation (SNF)
- European Research Council (ERC) [614847] Funding Source: European Research Council (ERC)
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Since its discovery in 1922, insulin has been thought to be required for normal metabolic homeostasis and survival. However, this view would need to be revised as recent results from different laboratories have convincingly indicated that life without insulin is possible in rodent models. These data indicate that particular neuronal circuitries, which include hypothalamic leptin-responsive neurons, are empowered with the capability of permitting life in complete absence of insulin. Here, we review the neuronal and peripheral mechanisms by which leptin signaling in the central nervous system (CNS) regulates glucose metabolism in an insulin-independent manner.
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