Journal
FRONTIERS IN MOLECULAR NEUROSCIENCE
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2015.00075
Keywords
rpS6 phosphorylation; mRNA translation; ribosome; mTOR; S6K; PP-1; brain; signaling cascades
Categories
Funding
- Inserm
- Fondation pour la Recherche Medicale
- Brain and Behavior Research Foundation
- Fonds National de la Recherche, Luxembourg [3977033]
- Marie Curie Intra-European Fellowship [IEF327648]
Ask authors/readers for more resources
Since the discovery of the phosphorylation of the 40S ribosomal protein S6 (rpS6) about four decades ago, much effort has been made to uncover the molecular mechanisms underlying the regulation of this post-translational modification. In the field of neuroscience, rpS6 phosphorylation is commonly used as a readout of the mammalian target of rapamycin complex 1 signaling activation or as a marker for neuronal activity. Nevertheless, its biological role in neurons still remains puzzling. Here we review the pharmacological and physiological stimuli regulating this modification in the nervous system as well as the pathways that transduce these signals into rpS6 phosphorylation. Altered rpS6 phosphorylation observed in various genetic and pathophysiological mouse models is also discussed. Finally, we examine the current state of knowledge on the physiological role of this post-translational modification and highlight the questions that remain to be addressed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available