Journal
FRONTIERS OF MATERIALS SCIENCE
Volume 9, Issue 3, Pages 211-226Publisher
HIGHER EDUCATION PRESS
DOI: 10.1007/s11706-015-0283-y
Keywords
drug delivery system (DDS); reduction-responsive; disulfide bond-containing polymer; tumor micro-environment responsive
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Funding
- National Natural Science Foundation of China [20904017]
- Program for New Century Excellent Talents in University [NCET-09-0441]
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Tumor micro-environment responsive drug delivery systems (DDSs) have been developed as a potential approach to reduce the side effects of cancer chemotherapy. Glutathione (GSH) has been supposed to the most significant signal of the difference between the normal tissue and the tumor cells, besides the media pH and temperature. In recent years, the reduction-responsive DDSs have attracted more and more attention for delivery of anti-cancer drugs, based on such physiological signal. Among them, disulfide bond-containing polymers have been designed as the main tool for the purpose. The recent progress in the synthesis strategies for the disulfide bond-containing polymer-based DDS is focused in the present review.
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