Journal
FEBS OPEN BIO
Volume 5, Issue -, Pages 147-154Publisher
WILEY
DOI: 10.1016/j.fob.2015.02.003
Keywords
Apoptosis; Breast cancer; Kruppel-like factor 4; Proliferation; Tumorigenicity
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Funding
- National Natural Science Foundation of China [31301143]
- Natural Science Foundation of Hebei Province [C2013201271]
- Hebei Youth Top-notch Talent Support Program
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Kruppel-like factor 4 (KLF4) functions as either a tumor suppressor or an oncogene in different tissues by regulating the expression of various genes. The aim of this study was to reveal the functions of KLF4 in regulating breast cancer apoptosis, proliferation, and tumorigenic progression. KLF4 expression levels in breast cancer tissues and breast cancer cell lines were found to be much lower than those in nontumorous tissues and a nontransformed mammary epithelial cell line. KLF4 was upregulated in the tumor necrosis factor-a-induced SK-BR-3 breast cancer cell apoptotic process. Overexpression of KLF4 promoted SK-BR-3 breast cancer cell apoptosis and suppressed SK-BR-3 cell tumorigenicity in vivo. (C) 2015 The Authors. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies. This is an open access article under the CC BY-NC-ND license
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