Journal
ALZHEIMERS RESEARCH & THERAPY
Volume 3, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/alzrt59
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Funding
- Janssen Pharmaceutica, Beerse
- US National Institutes of Health [U-01 AG032438]
- UK National Institute for Health Research and Medical Research Council
- Methusalem grant from the Flanders government
- KULeuven
- Medical Research Council [G0601846] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10123] Funding Source: researchfish
- NATIONAL INSTITUTE ON AGING [U01AG032438, U19AG010483] Funding Source: NIH RePORTER
- MRC [G0601846] Funding Source: UKRI
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Autosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of Alzheimer's disease. The present review summarizes clinical, pathological, imaging, biochemical, and molecular studies of autosomal-dominant Alzheimer's disease, highlighting the similarities and differences between the dominantly inherited form of Alzheimer's disease and the more common sporadic form of Alzheimer's disease. Current developments in autosomal-dominant Alzheimer's disease are presented, including the international Dominantly Inherited Alzheimer Network and this network's initiative for clinical trials. Clinical trials in autosomal-dominant Alzheimer's disease may test the amyloid hypothesis, determine the timing of treatment, and lead the way to Alzheimer's disease prevention.
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