Journal
ADVANCES IN NUTRITION
Volume 3, Issue 1, Pages 39-46Publisher
OXFORD UNIV PRESS
DOI: 10.3945/an.111.001271
Keywords
-
Categories
Funding
- University of Utah PEAK Academy
- American Diabetes Association Research Grant [7-08-RA-164]
- National Institutes of Health [R15 HL 091493-01]
- University of Utah College of Health grant
- Melaluca Inc.
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R15HL091493] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Epidemiological studies beginning in the 1990s have reported that intake of quercetin, a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is inversely related to cardiovascular disease. More recent work using hypertensive animals and humans (>140 mm Hg systolic and >90 mm Hg diastolic) indicates a decrease in blood pressure after quercetin supplementation. A number of proposed mechanisms may be responsible for the observed blood pressure decrease such as antioxidant effects, inhibition of angiotensin-converting enzyme activity, and improved endothelium-dependent and -independent function. The majority of these mechanisms have been identified using animal models treated with quercetin, and relatively few have been corroborated in human studies. The purpose of this review is to examine the evidence supporting the role of quercetin as a potential therapeutic agent and the mechanisms by which quercetin might exert its blood pressure lowering effect. Adv. Nutr. 3: 39-46, 2012.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available