Journal
ADVANCES IN NUTRITION
Volume 2, Issue 3, Pages 244-253Publisher
OXFORD UNIV PRESS
DOI: 10.3945/an.111.000398
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Funding
- NIH from the National Institute of Arthritis and Musculoskeletal and Skin Diseases [K23 AR054334]
- NIH from The National Institute of Diabetes and Digestive and Kidney Diseases [T32DK007734]
- NIH from the National Center for Research Resources [5UL1RR025008]
- Cystic Fibrosis Foundation Center
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Vitamin D is classically recognized for its role in calcium homeostasis and skeletal metabolism. Over the last few decades, vitamin D deficiency has increased in prevalence in adults and children. Potential extraskeletal effects of vitamin D have been under investigation for several diseases. Several cross-sectional studies have associated lower vitamin D status with decreased lung function. This finding has prompted investigators to examine the association of vitamin D deficiency with several chronic lung diseases. One major focus has been the link between maternal vitamin D status and childhood asthma. Vitamin D deficiency has also been associated with increased risk of respiratory infection from influenza A and Mycobacterium tuberculosis. Other chronic respiratory diseases associated with vitamin D deficiency include cystic fibrosis, interstitial lung disease, and chronic obstructive pulmonary disease. This review will examine the current clinical literature and potential mechanisms of vitamin D in various pulmonary diseases. Adv. Nutr. 2: 244-253, 2011.
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