Journal
ADVANCED HEALTHCARE MATERIALS
Volume 7, Issue 23, Pages -Publisher
WILEY
DOI: 10.1002/adhm.201800729
Keywords
chaperone-like activity; nanogel tectonics; nanogels; nanogel-tectonic materials; protein delivery; tissue engineering
Funding
- Exploratory Research for Advanced Technology from the Japan Science and Technology Agency (JST-ERATO) [JPMJER1101]
- Japan Society for the Promotion of Science (JSPS) [16H06313]
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Amphiphilic polysaccharide self-assembled (SA) nanogels are promising protein carriers owing to their chaperone-like activity that allows them to nanoencapsulate proteins within their polymer networks. The chaperoning function is an important concept that has led to breakthroughs in the development of effective protein drug delivery systems by stabilizing formulations and controlling the quality of unstable proteins. Recently, nanogel-tectonic materials that integrate SA nanogels as building blocks have been designed as new hydrogel biomaterials. This article describes recent progress and applications of SA nanogel tectonic materials as protein delivery systems for tissue engineering.
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