Journal
ADVANCED HEALTHCARE MATERIALS
Volume 7, Issue 21, Pages -Publisher
WILEY
DOI: 10.1002/adhm.201800457
Keywords
additive manufacturing; periodontal regeneration; scaffolds; tissue engineering
Funding
- Queensland University of Technology
- University of Michigan Rackham Merit Fellowship
- NIH/NIDCR Tissue Engineering at Michigan (TEAM) trainee grant [DE 007057]
- NIH/NIDCR [RO1 DE 13397, U24 DE026915]
- Australian Research Council under the ARC Training Centre in Additive Biomanufacturing
- NHMRC [1086181]
- National Health and Medical Research Council of Australia [1086181] Funding Source: NHMRC
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The periodontium, consisting of gingiva, periodontal ligament, cementum, and alveolar bone, is a hierarchically organized tissue whose primary role is to provide physical and mechanical support to the teeth. Severe cases of periodontitis, an inflammatory condition initiated by an oral bacterial biofilm, can lead to significant destruction of soft and hard tissues of the periodontium and result in compromised dental function and aesthetics. Although current treatment approaches can limit the progression of the disease by controlling the inflammatory aspect, complete periodontal regeneration cannot be predictably achieved. Various tissue engineering approaches are investigated for their ability to control the critical temporo-spatial wound healing events that are essential for achieving periodontal regeneration. This paper reviews recent progress in the field of periodontal tissue engineering with an emphasis on advanced 3D multiphasic tissue engineering constructs (TECs) and provides a critical analysis of their regenerative potential and limitations. The review also elaborates on the future of periodontal tissue engineering, including scaffold customization for individual periodontal defects, TEC's functionalization strategies for imparting enhanced bioactivity, periodontal ligament fiber guidance, and the utilization of chair-side regenerative solutions that can facilitate clinical translation.
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