Journal
ADVANCED HEALTHCARE MATERIALS
Volume 7, Issue 19, Pages -Publisher
WILEY
DOI: 10.1002/adhm.201800602
Keywords
Bi2S3@MSN; mitochondrial apoptosis pathway; osteosarcoma; photothermal therapy-chemotherapy; X-ray computed tomography
Funding
- National Key Research Program of China [2017YFB0702604]
- National Natural Science Foundation of China [31771038, 81402409]
- Fundamental Research Funds for the Central Universities
- Hundred, Thousand and Ten Thousand Leading Talent Project in Guangdong Program for Special Support of Eminent Professionals
- Natural Science Foundation of Guangdong Province, China [2015A030312004]
- Scientific and Technological Projects of Guangzhou, China [201604020110]
- National Institutes of Health [R01MH103133, R21GM126532]
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Despite its 5-year event-free survival rate increasing to 60-65% due to surgery and chemotherapy, osteosarcoma (OS) remains one of the most threatening malignant human tumors, especially in young patients. Therefore, a new approach that combines early diagnosis with efficient tumor eradication and bioimaging is urgently needed. Here, a new type of mesoporous silica-coated bismuth sulfide nanoparticles (Bi2S3 @ MSN NPs) is developed. The well distributed mesoporous pores and large surface areas hold great promise for drug protection and encapsulation (doxorubicin (DOX), 99.85%). Moreover, the high photothermal efficiency of Bi2S3 @ MSNs (36.62%) offers great possibility for cancer synergistic treatment and highly near-infrared-triggered drug release (even at an ultralow power density of 0.3 W cm(-2)). After covalently conjugated to arginine-glycine-aspartic acid (RGD) peptide [c(RGDyC)], the NPs exhibit a high specificity for osteosarcoma and finally accumulate in the tumor cells (tenfold more than peritumoral tissues) for computed tomography (CT) imaging and tumor ablation. Importantly, the synergistic photothermal therapy-chemotherapy of the RGD-Bi2S3 @ MSN/DOX significantly ablates the highly malignant OS. It is further proved that the superior combined killing effect is achieved by activating the mitochondrial apoptosis pathway. Hence, the smart RGD-Bi2S3 @ MSN/DOX theranostic platform is a promising candidate for future applications in CT monitoring and synergistic treatment of malignant tumors.
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