Journal
ADVANCED HEALTHCARE MATERIALS
Volume 3, Issue 1, Pages 70-78Publisher
WILEY
DOI: 10.1002/adhm.201300076
Keywords
catheter injection; drug delivery; myocardial infarction; pH-responsive hydrogel; supramolecular polymers
Funding
- NWO Toptalent Fellowship
- HGG group B.V.
- Wijnand M. Pon Stichting
- Dutch government
- European Research Council (ERC)
- Council for Chemical Sciences of the Netherlands Organization for Scientific Research (CW-NWO)
- Dutch Ministry of Economic Affairs, Agriculture and Innovation
- Nederlandse Hartstichting
- Dutch Ministry of Education, Culture and Science [024.001.035]
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Minimally invasive intervention strategies after myocardial infarction use state-of-the-art catheter systems that are able to combine mapping of the infarcted area with precise, local injection of drugs. To this end, catheter delivery of drugs that are not immediately pumped out of the heart is still challenging, and requires a carrier matrix that in the solution state can be injected through a long catheter, and instantaneously gelates at the site of injection. To address this unmet need, a pH-switchable supramolecular hydrogel is developed. The supramolecular hydrogel is switched into a liquid at pH > 8.5, with a viscosity low enough to enable passage through a 1-m long catheter while rapidly forming a hydrogel in contact with tissue. The hydrogel has self-healing properties taking care of adjustment to the injection site. Growth factors are delivered from the hydrogel thereby clearly showing a reduction of infarct scar in a pig myocardial infarction model.
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