Journal
ADVANCED HEALTHCARE MATERIALS
Volume 3, Issue 2, Pages 290-299Publisher
WILEY
DOI: 10.1002/adhm.201300215
Keywords
biocompatibility; homogeneous blends; radiopacity; resorbable biomaterials; stents
Funding
- EU (through Interreg IV-A)
- government of the Province Dutch Limburg
- Dutch National Ministery of Economic Affairs, Agriculture Innovation
- Maastricht University
- Limburg Bank for Industry Innovation (LIOF)
- company INterface BIOmaterials BV in Geleen, Netherlands
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Bioresorbable coronary vascular scaffolds are about to revolutionize the landscape of interventional cardiology. These scaffolds, consisting of a poly(L-lactic acid) interior and a poly(d,l-lactic acid) surface coating, offer a genuine alternative for metallic coronary stents. Perhaps the only remaining drawback is that monitoring during implantation is limited to two X-ray contrast points. Here, a new approach to make the biodegradable scaffolds entirely radiopaque is explored. A new contrast agent is designed and synthesized. This compound is miscible with poly(d,l-lactic acid) matrix, and nontoxic to multiple cell types. Blends of poly(d,l-lactic acid) and the contrast agent are found to be hemocompatible, noncytotoxic, and radiopaque. The data show that it is possible to manufacture fully radiopaque bioresorbable coronary vascular scaffolds. Whole-stent X-ray visibility helps interventionalists ensure that the scaffold deploys completely. This important advantage may translate into improved safety, accuracy, and clinical performance of cardiac stents.
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