Journal
ADVANCED HEALTHCARE MATERIALS
Volume 1, Issue 6, Pages 751-761Publisher
WILEY-BLACKWELL
DOI: 10.1002/adhm.201200094
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Funding
- University at Buffalo
- National Science Foundation [CBET-1019227, 1133737]
- National Institute of Health [NIDA-1R21DA030108-01, K01DA024577]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1133737] Funding Source: National Science Foundation
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Well-defined tertiary amine-functionalized cationic polylactides (CPLAs) are synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide, and utilized for the delivery of interleukin-8 (IL-8) siRNA via CPLA-IL-8 siRNA nanoplexes. The CPLAs possess remarkable hydrolytic degradability, and their cytotoxicity is relatively low. The CPLA-IL-8 siRNA nanoplexes can be readily taken up by prostate cancer cells, resulting in significant IL-8 gene silencing. It is found that the degradability and cytotoxicity of CPLAs, as well as the transfection efficiency of the CPLA-IL-8 siRNA nanoplexes, positively correlate with the amine mol% of CPLAs.
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