Journal
ADVANCED HEALTHCARE MATERIALS
Volume 1, Issue 6, Pages 714-721Publisher
WILEY
DOI: 10.1002/adhm.201200084
Keywords
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Funding
- Canadian Institute of Health Research
- Canadian Breast Cancer Research Alliance [MOP - 193110, RMF111623]
- Natural Sciences and Engineering Research Council [RGPIN 288231-09]
- Canadian Foundation for Innovation
- Ontario Centre of Excellence
- Ministry of Research and Innovation
- Natural Sciences and Engineering Research Council
- Natural Sciences and Engineering Research Council (BIOPSYS Network)
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Nanoparticle vehicles may improve the delivery of contrast agents and therapeutics to diseased tissues, but their rational design is currently impeded by a lack of robust technologies to characterize their in vivo behavior in realtime. This study demonstrates that fluorescent-labeled gold nanoparticles can be optimized for in vivo detection, perform pharmacokinetic analysis of nanoparticle designs, analyze tumor extravasation, and clearance kinetics in tumor-bearing animals. This optical imaging approach is non-invasive and high-throughput. Interestingly, these fluorescent gold nanoparticles can be used for multispectral imaging to compare several nanoparticle designs simultaneously within the same animal and eliminates the host-dependent variabilities across measured data. Together these results describe a novel platform for evaluating the performance of tumor-targeting nanoparticles, and provide new insights for the design of future nanotherapeutics.
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