Journal
ACS MACRO LETTERS
Volume 7, Issue 9, Pages 1073-1079Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmacrolett.8b00610
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Funding
- Natural Science Foundation of China (NSFC) [21622402, 51673057, 21574036]
- Fundamental Research Funds for the Central Universities of China
- Anhui Provincial Natural Science Foundation [1608085MB41]
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In this manuscript, we designed and synthesized three core cross-linked micelles (M-5L, P-5L, and P-5D) with redox-responsive disulfide bonds in the core and carrying optically active helical polyisocyanide arms. Their arms were different in the helicity of the main chain and the chirality of the side groups. These micelles showed excellent redox-responsiveness to reducing agent. However, because of the different chiralities of the arms, the three micelles exhibited different performances in drug delivery and controlled release. The M-5L micelle carrying left-handed helical arms showed better therapeutic effect than the other two due to the rapid cell membrane permeability.
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