Journal
ACS MACRO LETTERS
Volume 3, Issue 10, Pages 1064-1068Publisher
AMER CHEMICAL SOC
DOI: 10.1021/mz500479k
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Funding
- CSIR-NCL
- DST-Nanomission
- IYBA (DBT)
- UGC
- CSIR
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Despite the promising photophysical properties of fluorescent graphene quantum dots (GQDs), their cellular toxicity needs to be addressed before their full potential could be completely realized in biomedicine. A simple method for mitigating the toxicity of GQDs by embedding them in PEG matrix is reported here. The enhanced biocompatibility of polymer modified, P-GQDs, is attributed to reduced reactive oxygen species generation, as measured by an intracellular ROS assay. We also demonstrate the enhanced loading and efficient intracellular delivery of therapeutics by P-GQDs.
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