Journal
ACS MACRO LETTERS
Volume 3, Issue 5, Pages 472-476Publisher
AMER CHEMICAL SOC
DOI: 10.1021/mz500181q
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Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- le Fonds de recherche du Quebec: Nature et technologies (FRQNT)
- FRQNT
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A novel supramolecular block glycopolypeptide, designed to have the viral building blocks and be sensitive to CO2, a physiological stimulus, was prepared via the orthogonal coupling of two end-functionalized biopolymers, dextran with beta-cyclodextrin terminal (Dex-CD) and poly(L-valine) with a benzimidazole tail (BzI-PVal), respectively, driven by the end-to-end host guest interactions. Due to the CO2-cleavable CD/BzI connection, both the vesicular and fibrous aggregates of this supramolecular block copolymer self-assembled in aqueous solution can undergo a reversible process of disassembly upon breathing in CO2 and assembly upon breathing out CO2, which mimics, to some extent, the disintegration and construction of viral capsid nanostructures.
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