Journal
ACS MACRO LETTERS
Volume 2, Issue 9, Pages 809-813Publisher
AMER CHEMICAL SOC
DOI: 10.1021/mz4003672
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Funding
- NSF [CHE-1153122, DMR-1150742]
- NIH [1DP2OD007246]
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Amphiphilic polypeptide-containing hybrid dual brush block copolymers with controlled molecular weights and narrow molecular weight distributions were synthesized in one pot via ring-opening metathesis polymerization of sequentially added norbornyl-PEG and N-(2-((trimethylsilyl)amino)ethyl)-5-norbornene-endo-2,3-dicarboximide (M1), followed by ring-opening polymerization of amino acid N-carboxyanhydrides. Polylactide nanoparticles coated with these amphiphilic dual brush block copolymers showed significantly improved stability in PBS solution compared to those coated with amphiphilic linear block copolymers such as PEG-polylactide and PEG-polypeptides.
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