Journal
ACS MACRO LETTERS
Volume 2, Issue 11, Pages 1021-1025Publisher
AMER CHEMICAL SOC
DOI: 10.1021/mz400480z
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Funding
- National Natural Science Foundation of China [21074095, 21174107, 21274110, 21374080]
- Shanghai 1000 Plan
- New Century Excellent Talents in Universities of MOE [NCET-10-0627]
- Ph.D. Program Foundation of MOE [20110072110048]
- Fok Ying Tong Education Foundation [132018]
- fundamental research funds for the central universities
- Bayer Science and Education Foundation
- Bayer-Tongji Eco-Construction and Material Academy [TB20120004]
- open fund for characterization at Tongji University [0002012025, 0002012022]
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Antibacterial polypeptides as ancient immune defense systems are effective against bacteria. Here we report a novel kind of armed carrier: an antibacterial polypeptide-grafted chitosan-based nanocapsule with an excellent antibacterial efficacy against both Gram-positive and Gram-negative bacteria. This nanocapsule also has excellent blood compatibility and low cytotoxicity. Patients after tumor surgery may benefit from this armed carrier because it is highly anti-inflammation and is able to deliver anticancer and antiepileptic drugs simultaneously.
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