Journal
ACS MACRO LETTERS
Volume 2, Issue 3, Pages 201-205Publisher
AMER CHEMICAL SOC
DOI: 10.1021/mz300568b
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Funding
- National Natural Science Foundation of China [51125014, 51233003]
- Ministry of Science and Technology of China [2011CB606202]
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Novel drug carriers based on poly(ethylene glycol) PEG-polypeptide copolymers, four-armed poly(epsilon-adamantane-L-lysine)(2)-block-poly(ethylene glycol)-block-poly-(epsilon-adamantane-L-lysine)(2) (PLys(Ad)(2)-b-PEG-b-PLys(Ad)(2)), have been prepared. The copolymers were synthesized via the ring-opening polymerization of amino acid N-carboxyanhydrides. The copolymers could spontaneously form core-shell micelles in aqueous solutions. It has been found that these micelles undergo triggered disassembly in response to an additional beta-cyclodextrin (beta-CD). The in vitro drug release beta-response to CD has been studied, and the result shows that the release of the entrapped drug doxorubicin (DOX) from the micelles could be accelerated by the addition of beta-CD. Their cytotoxicity and cell internalization behavior were also investigated in detail. These micelles are expected to have great potential in controlled drug release applications.
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