Journal
ACS MACRO LETTERS
Volume 2, Issue 8, Pages 710-714Publisher
AMER CHEMICAL SOC
DOI: 10.1021/mz400370f
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Funding
- National Science Foundation (NSF) [CHE-0645737]
- Vanderbilt Institute of Chemical Biology for a Chemistry-Biology Interface Program Fellowship under the NIH Training Grant [T32 GMO65086-5]
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Water-soluble semiconducting nanoparticles are prepared from individually collapsed and cross-linked ABA triblock copolymers and are further modified to carry imaging units and allyl functionalities for postmodification. Ethylene oxide modified polyfluorene forms the center block (B) and is transformed into a telechelic macroinitiator. In a nitroxide-mediated living free radical polymerization, polyacrylate blocks (A) are grown to give the ABA triblock copolymer. Low-temperature benzocyclobutene cross-linking groups are attached to collapse and site-isolate the center block (A). The nanoparticles were further modified by pegylation to enhance the solubility and by catechol groups to provide complexing sites for magnetic resonance imaging (MRI) reagents such as gadolinium. The reported materials are water-soluble and encompassing fluorescence and MRI to become biocompatible organic quantum dots with the possibility to interact actively with biological entities.
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