Journal
ACS MACRO LETTERS
Volume 2, Issue 6, Pages 491-495Publisher
AMER CHEMICAL SOC
DOI: 10.1021/mz400173c
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Funding
- Basque Government
- European Commission [283883]
- [MAT2012-31088]
- [IT-654-13]
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We report herein a very efficient synthesis strategy for the construction of artificial transient-binding protein-mimic nano-objects. Michael addition-mediated multidirectional self-assembly of individual polymeric chains at r.t. leads to Michael nanocarriers that in solution resemble disordered multidomain proteins, as revealed by a combination of small angle neutron scattering measurements and coarse-grained molecular dynamics simulation results, whereas in the dry state adopt a collapsed, globular morphology, as observed by transmission electron microscopy. This extended-to-compact morphology transition taking place upon solvent removal is of paramount importance, among other applications, for the construction of efficient biosensors based on immobilized protein-mimic nano-objects and for the development of transient vitamin-binding systems. As a proof of concept, we show the controlled delivery of vitamin B-9 from these novel transient-binding nanocarriers.
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