Journal
ACS MACRO LETTERS
Volume 1, Issue 5, Pages 529-532Publisher
AMER CHEMICAL SOC
DOI: 10.1021/mz300047c
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Funding
- National Science Foundation [CAREER DMR-0846792]
- Alfred P. Sloan Research Fellowship
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1265388] Funding Source: National Science Foundation
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Well-defined boronic acid block copolymers were demonstrated to exhibit glucose-responsive disassembly at physiological pH. A boronic acid-containing acrylamide monomer with an electron-withdrawing substituent on the pendant phenylboronic acid moiety was polymerized by reversible addition-fragmentation chain transfer (RAFT) polymerization to yield a polymer with a boronic acid pK(a) = 8.2. Below this value, a block copolymer of this monomer with poly(N,N-dimethylacrylamide) self assembled into aggregates. Addition of base to yield a pH > pK(a) or addition of glucose at pH = 7.4 resulted in aggregate dissociation that may prove promising for controlled delivery applications under physiological relevant conditions.
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