Journal
ACS MACRO LETTERS
Volume 1, Issue 4, Pages 489-493Publisher
AMER CHEMICAL SOC
DOI: 10.1021/mz300063g
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Funding
- National Natural Science Foundation of China [20604024, 50802088]
- Natural Science Foundation of Zhejiang Province [Y4100045, Y4080392, R210101054]
- Qianjiang Talents Project of Zhejiang Province [2010R10023]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, the State Education Ministry [1001603-C]
- Training Foundation for the Excellent Young Talents by the Key Laboratory of Advanced Textile Materials and Manufacturing Technology (ATMT)
- Ministry of Education [2011QN04]
- Program for Changjiang Scholars and Innovative Research Team in University [PCSIRT: 0654]
- Innovative Program for Graduate Students of Zhejiang Sci-Tech University [YCX-S11006]
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Redox-sensitive shell cross-linked (SCL) poly-(2-(dimethylamino)ethyl methacrylate)-block-polystyrene (PDMAEMA-b-PS) nanoparticles have been facilely fabricated by surfactant-free emulsion reversible addition-fragmentation chain transfer polymerization (SFE-RAFT), in which amphiphilic C12H25-PDMAEMA copolymers acted as stabilizers. H-1 NMR, dynamic light scattering (DLS), and transmission electron microscopy (TEM) were applied to investigate the compositions and the morphologies of the resultant nanoparticles. Then, the as-prepared nanoparticles were used as a carrier to encapsulate of hydrophobic drugs, and the release could be triggered by a redox reagent, dithiothreitol (DTT). The SCL nanoparticles had a good biocompatibility. These properties indicated that these nanoparticles would be used as promising drug delivery vehicles.
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