Journal
ACS MACRO LETTERS
Volume 1, Issue 5, Pages 564-567Publisher
AMER CHEMICAL SOC
DOI: 10.1021/mz300083y
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Funding
- U.S. National Science Foundation [CHE-0723497]
- Deutsche Forschunsgemeinschaft (DFG) [HA 2549/10-1]
- Frauenforderung der FU Berlin
- Allergan Foundation
- UCI Department of Chemistry
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A water-soluble molecular transporter with a dendritic core-shell nanostructure has been prepared by a tandem coordination, ring-opening, hyperbranched polymerization process. Consisting of hydrophilic hyperbranched polyglycerol shell grafted from hydrophobic dendritic polyethylene core, the transporter has a molecular weight of 951 kg/mol and a hydrodynamic diameter of 17.5 +/- 0.9 nm, as determined by static and dynamic light scattering, respectively. Based on evidence from fluorescence spectroscopy, light scattering, and electron microscopy, the core-shell copolymer transports the hydrophobic guests pyrene and Nile red by a unimolecular transport mechanism. Furthermore, it was shown that the core-shell copolymer effectively transports the hydrophobic dye Nile red into living cells under extremely high and biologically relevant dilution conditions, which is in sharp contrast to a small molecule amphiphile. These results suggest potential applicability of such core-shell molecular transporters in the administration of poorly water-soluble drugs.
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