Journal
ACS MACRO LETTERS
Volume 1, Issue 10, Pages 1208-1211Publisher
AMER CHEMICAL SOC
DOI: 10.1021/mz300375c
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Funding
- National Basic Research Program [2009CB930400, 2012CB821500]
- National Natural Science Foundation of China [20974062]
- China National Funds for Distinguished Young Scientists [21025417]
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By a combination of excellent fluorescent performance with smart targeting capability for cancer-specific delivery, a promising class of calcein-based supramolecular fluorescent nanoparticles has been successfully prepared via a bricks and mortar strategy. Through tuning the molar ratio of adamantane-functionalized calcein (CA-AD)/beta-cyclodextrin-grafted branched polyethylenimine (PEI-CD), the size of these fluorescent nanoparticles can be effectively controlled. Importantly, the beta-cyclodextrin/adamantane (beta-CD/AD = 1/1) host-guest interaction dramatically suppresses the pi-pi stacking and fluorescence self-quenching of calcein chromophores in water, leading to the formation of highly fluorescent nanoparticles. By introduction of the folate receptor, these fluorescent nanoparticles exhibit excellent cancer imaging efficiency.
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