Journal
ACS MACRO LETTERS
Volume 1, Issue 2, Pages 328-333Publisher
AMER CHEMICAL SOC
DOI: 10.1021/mz200226m
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Funding
- National Heart Lung and Blood Institute of the National Institutes of Health [HHSN268201000046C]
- National Science Foundation [DMR-0906815, DMR-1105304]
- Welch Foundation [A-0001]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [0906815] Funding Source: National Science Foundation
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Click chemistry is a library of efficient and reliable reactions, which have been used to functionalize various classes of bio- and synthetic macromolecular systems for the incorporation of designed properties and functions. In this report, azide-alkyne Huisgen cycloaddition and thiol-yne reactions, two classical click chemistries, were employed to functionalize biodegradable, clickable polyphosphoester homopolymers, and their water-soluble copolymers. A stable alkyne-functionalized phospholane monomer was synthesized, its organocatalyzed polymerization kinetics were evaluated, and the resulting (co)polymers were utilized to develop this facile method that provides the synthesis of clickable, water-soluble, and degradable polyphosphoesters, which can be adapted for various applications.
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