Facile and Rapid Access to Glyconanocapsules by CuAAC Interfacial Polyaddition in Miniemulsion Conditions

Glyconanocapsules with a biocompatible oily core have been successfully prepared by copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) interfacial step growth polymerization between 6,6'-diazido-6,6'-dideoxysucrose and bis(propargyloxy)butane in oil-in-water miniemulsion conditions. Optimization of the interfacial polymerization process in dispersed medium afforded the rapid and reproducible preparation of stable monodispersed glyconanocapsules having a diameter around 200 nm.