Journal
VIRULENCE
Volume 10, Issue 1, Pages 438-447Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21505594.2018.1518102
Keywords
Toxoplasma gondii; toxoplasmosis; autophagy; non-canonical autophagy; LC3-associated phagocytosis (LAP)
Categories
Funding
- Institut National de la Sante et de la Recherche Medicale (Inserm)
- Fondation pour la Recherche Medicale [Equipe EQ20170336725]
- Labex Parafrap [ANR-11-LABX-0024]
Ask authors/readers for more resources
Toxoplasma gondii is an obligate intracellular parasitic protist that infects a wide range of warm-blooded vertebrates. Although this parasite can cause serious complications, infections are often asymptomatic, allowing T. gondii to persist in its host and possibly enhancing the chances of its transmission. T. gondii has thus evolved multiple mechanisms of host manipulation to establish chronic infection. This persistence involves a balance between host immunity and parasite evasion of this immune response. This review highlights recent investigations that have demonstrated the important role played by the autophagy machinery in this balance, both in parasite control by the host, and in host exploitation by the parasite.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available