Journal
VIRULENCE
Volume 5, Issue 4, Pages 477-497Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/viru.28595
Keywords
zoonosis; Streptococcus suis; pathogenesis
Categories
Funding
- startup package of Zhejiang University, China
- National Natural Science Foundation of China [31170124, 81371768, 81172794, 31300119]
- National S&T Project for Infectious Diseases Control [2013ZX10004-103, 2013ZX10004-203, 2013ZX10004-218]
- Young 1000 Talents Award
- Department of Epidemiology, Research Institute for Medicine of Nanjing Command
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Streptococcus suis (S. suis) is a family of pathogenic gram-positive bacterial strains that represents a primary health problem in the swine industry worldwide. S. suis is also an emerging zoonotic pathogen that causes severe human infections clinically featuring with varied diseases/syndromes (such as meningitis, septicemia, and arthritis). Over the past few decades, continued efforts have made significant progress toward better understanding this zoonotic infectious entity, contributing in part to the elucidation of the molecular mechanism underlying its high pathogenicity. This review is aimed at presenting an updated overview of this pathogen from the perspective of molecular epidemiology, clinical diagnosis and typing, virulence mechanism, and protective antigens contributing to its zoonosis.
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