Journal
VIRULENCE
Volume 5, Issue 1, Pages 66-72Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/viru.26907
Keywords
sepsis; mitochondria; multi-organ failure; nitric oxide; reactive oxygen species; biogenesis; mitophagy
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An important role for bioenergetic dysfunction is increasingly emerging to potentially explain the paradox of clinical and biochemical organ failure in sepsis yet minimal cell death, maintained tissue oxygenation and recovery in survivors. Associations are well-recognized between the degree of mitochondrial dysfunction and outcomes. While this does not confirm cause-and-effect, it does nevertheless suggest a new route for therapeutic intervention focused on either mitochondrial protection or acceleration of the recovery process through stimulation of mitochondrial biogenesis (new protein turnover). This is particularly pertinent in light of the multiple trial failures related to immunomodulatory therapies. This overview will provide insights into mitochondrial biology, the relevance to sepsis, and therapeutic opportunities that possibly emerge.
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