Journal
VIRULENCE
Volume 3, Issue 7, Pages 635-646Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/viru.22295
Keywords
plasmacytoid dendritic cells; conventional dendritic cells; fungi; Toll-like receptors; scavenger receptors
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Funding
- NIAID NIH HHS [T32 AI007061, R01 AI084884] Funding Source: Medline
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Dendritic cells (DCs) are the bridge between the innate and adaptive immune system. DCs are responsible for sensing and patrolling the environment, initiating a host response and instructing the proper adaptive immune response against pathogens. Recent advances in medical treatments have led to increased use of immunosuppressive drugs, leading to the emergence of fungal species that cause life-threatening infections in humans. Three of these opportunistic fungal pathogens: Aspergillus fumigatus, Candida albicans and Cryptococcus neoformans pose the biggest concern for the immune-compromised host. Here we will review the interactions between DCs and these fungal pathogens, the receptors expressed on DCs that mediate these responses and the signaling mechanisms that shape the adaptive host response.
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