Journal
VIRULENCE
Volume 3, Issue 3, Pages 262-270Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/viru.20266
Keywords
inflammasome; caspase-1; immune evasion; immunopathology; virulence; pathogenicity
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Funding
- US National Institutes of Health [AR056296, AI1010935]
- American Syrian Lebanese Associated Charities
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Pathogens frequently exist in an immunological balancing act with their host. Pathogens must not only replicate within a host but also transmit effectively between hosts to perpetuate their species. On the other hand, the host seeks to maintain homeostasis by clearing pathogens. The inflammasome is a multi-protein complex that can induce cell death and processes IL-1 beta and additional proinflammatory substrates. In this review we discuss the pathogen specific modulation of inflammasome activation and the role this plays in virulence and disease pathology.
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