Journal
VIRULENCE
Volume 3, Issue 2, Pages 182-192Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/viru.19004
Keywords
Toxoplasma gondii; blood-brain barrier; cytokines; endothelial cells; astrocytes
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Funding
- Wellcome Trust [087582, 085349] Funding Source: Medline
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Infection with the protozoan parasite Toxoplasma gondii is characterized by asymptomatic latent infection in the central nervous system and skeletal muscle tissue in the majority of immunocompentent individuals. Life-threatening reactivation of the infection in immunocompromized patients originates from rupture of Toxoplasma cysts in the brain. While major progress has been made in our understanding of the immunopathogenesis of infection the mechanism(s) of neuroinvasion of the parasite remains poorly understood. The present review presents the current understanding of blood-brain barrier (patho)physiology and the interaction of Toxoplasma gondii with cells of the blood-brain barrier.
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