Journal
VIRULENCE
Volume 3, Issue 3, Pages 251-261Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/viru.20010
Keywords
Candida albicans; phenotypic transitions; white-opaque switching; cAMP-PKA pathway; filamentous development
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Funding
- Chinese Academy of Sciences
- Chinese National Natural Science Foundation Grant [31170086]
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The human commensal fungus Candida albicans can cause not only superficial infections, but also life-threatening disease in immunocompromised individuals. C. albicans can grow in several morphological forms. The ability to switch between different phenotypic forms has been thought to contribute to its virulence. The yeast-filamentous growth transition and white-opaque switching represent two typical morphological switching systems, which have been intensively studied in C. albicans. The interplay between environmental factors and genes determines the morphology of C. albicans. This review focuses on the regulation of phenotypic changes in this pathogenic organism by external environmental cues and internal genes.
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