Journal
VIRULENCE
Volume 2, Issue 2, Pages 166-169Publisher
LANDES BIOSCIENCE
DOI: 10.4161/viru.2.2.15481
Keywords
RIG-I; Sendai; influenza; PAMP; PRR
Categories
Funding
- NIAID NIH HHS [T32 AI007647, U01 AI070469, R01 AI046954, U19 AI083025, U19 AI062623, U01AI70469, U54-AI057158, U19AI62623, U54 AI057158, 2T32AI007647-11, P01AI58113, P01AI82325, U19AI83025, P01 AI082325, R01AI46954, HHSN266200700010C, P01 AI058113] Funding Source: Medline
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Retinoic acid inducible gene I (RIG-I) is a pattern recognition receptor (PRR) responsible for detection of nucleic acids from pathogens in the cytoplasm of infected cells and induction of type I interferon (IFN). RIG-I-specific pathogen associated molecular patterns (PAMPs) are characterized by RNA molecules with a 5'-triphosphate (5'-ppp) group and partial double-stranded composition. Although many RNA molecules capable of activating RIG-I have been described, the exact nature of viral RNAs that are responsible for triggering RIG-I activity during the course of an infection has not been extensively explored and the specificity of RIG-I for various viral RNA molecules remains largely unknown. By examining endogenous RIG-I/RNA complexes in influenza virus-and Sendai virus-infected cells we were able to identify viral RNA molecules that specifically associated with RIG-I during infection. We showed that in Sendai virus-infected cells, RIG-I specifically and preferentially associated with the copy-back defective interfering (DI) particle RNA and not with the full-length Sendai virus genome or Sendai virus encoded mRNAs. In influenza virus-infected cells RIG-I also preferentially associated with DI RNAs as well as with the shorter genomic segments.
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