Journal
VIRULENCE
Volume 1, Issue 4, Pages 330-332Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/viru.1.4.12364
Keywords
heat shock response; Hsf1; Hsp90; transcriptional regulation; fungal pathogenesis; fungal morphogenesis
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Funding
- BBSRC [BB/F00513X/1, BB/D009308/1, BB/F000111/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F00513X/1, BB/D009308/1, BB/F000111/1] Funding Source: Medline
- Wellcome Trust [080088] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BB/F00513X/1, BB/F000111/1, BB/D009308/1] Funding Source: researchfish
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Despite being obligately associated with warm-blooded animals, Candida albicans expresses a bona fide heat shock response that is regulated by the evolutionarily conserved, essential heat shock transcription factor Hsf1. Hsf1 is thought to play a fundamental role in thermal homeostasis, adjusting the levels of essential chaperones to changes in growth temperature, for example in febrile patients. Hsf1 also regulates the expression of Hsp90, which controls the yeast-hypha transition in C. albicans, and we argue, might also control morphogenesis in other fungal pathogens of humans.
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