Journal
VIRULENCE
Volume 1, Issue 3, Pages 197-201Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/viru.1.3.11053
Keywords
Cryptococcus; virulence; mitochondrion; intracellular parasitism; mitochondrial fusion; Vancouver Island outbreak; macrophage
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Funding
- Medical Research Council [G0601171] Funding Source: researchfish
- MRC [G0601171] Funding Source: UKRI
- Medical Research Council [G0601171] Funding Source: Medline
- Wellcome Trust [WT088148MF] Funding Source: Medline
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In our recent paper, we demonstrated that the hypervirulence exhibited by a lineage of the fatal fungal pathogen Cryptococcus gattii is associated with its mitochondrial gene expression and an unusual mitochondrial morphology. As an important organelle, the mitochondrion has been linked to various cellular activities, but its role in modulating virulence of pathogens remains unclear. In this addendum, the potential role of mitochondria in determining virulence in eukaryotic pathogens is discussed along with future experiments that may lead to an improved understanding of this topic.
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