Journal
THORACIC CANCER
Volume 5, Issue 6, Pages 473-486Publisher
WILEY
DOI: 10.1111/1759-7714.12143
Keywords
Cancer; Notch signaling pathway; oncogene; targeted therapeutics; tumor suppressor gene
Categories
Funding
- Guangxi Ministry of Education [YCSZ2012050, 201202ZD022, 201201ZD004]
- National Natural Science Foundation of China (NSFC) [81130046, NSFC81171993, NSFC81272415]
- Guangxi Key Projects [2013GXNSFEA053004]
- Guangxi Projects [1355004-5, 2012GXNSFCB053004]
- National Institutes of Health (NIH) [P01 CA093900]
- 973 project [2010CB529405]
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Despite advances in surgery, imaging, chemotherapy, and radiotherapy, the poor overall cancer-related death rate remains unacceptable. Novel therapeutic strategies are desperately needed. Nowadays, targeted therapy has become the most promising therapy and a welcome asset to the cancer therapeutic arena. There is a large body of evidence demonstrating that the Notch signaling pathway is critically involved in the pathobiology of a variety of malignancies. In this review, we provide an overview of emerging data, highlight the mechanism of the Notch signaling pathway in the development of a wide range of cancers, and summarize recent progress in therapeutic targeting of the Notch signaling pathway.
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