Journal
THERANOSTICS
Volume 4, Issue 11, Pages 1112-1122Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.9710
Keywords
LiGa5O8:Cr3+ nanoparticles; near-infrared; persistent luminescence; photostimulated persistent luminescence; in vivo imaging
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Funding
- NSF CAREER award [DMR-0955908]
- NCI/NIH [5R00CA153772]
- Intramural Research Program of NIBIB, NIH
- NIH [R01HL093339, GM103390]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [0955908] Funding Source: National Science Foundation
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In vivo fluorescence imaging suffers from suboptimal signal-to-noise ratio and shallow detection depth, which is caused by the strong tissue autofluorescence under constant external excitation and the scattering and absorption of short-wavelength light in tissues. Here we address these limitations by using a novel type of optical nanoprobes, photostimulable LiGa5O8:Cr3+ near-infrared (NIR) persistent luminescence nanoparticles, which, with very-long-lasting NIR persistent luminescence and unique photo-stimulated persistent luminescence (PSPL) capability, allow optical imaging to be performed in an excitation-free and hence, autofluorescence-free manner. LiGa5O8:Cr3+ nanoparticles pre-charged by ultraviolet light can be repeatedly (>20 times) stimulated in vivo, even in deep tissues, by short-illumination (similar to 15 seconds) with a white light-emitting-diode flashlight, giving rise to multiple NIR PSPL that expands the tracking window from several hours to more than 10 days. Our studies reveal promising potential of these nanoprobes in cell tracking and tumor targeting, exhibiting exceptional sensitivity and penetration that far exceed those afforded by conventional fluorescence imaging.
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