Journal
THERANOSTICS
Volume 4, Issue 12, Pages 1233-1238Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.10330
Keywords
hydrogen sulfide; fluorescent probe; cell imaging; aggregation-induced emission
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Here we reported the first fluorescent probe with aggregation-induced emission characteristics, namely AIE-S, for the detection of hydrogen sulfide (H2S) in live cells. The detection system is selective for complicated biological application and the response is fast enough to complete within seconds. Moreover, the probe exhibits the unique advantage of being immune to aggregation-caused quenching which is a detrimental phenomenon limiting the application of most current available H2S fluorescent probes. The detection mechanism was investigated and postulated to be S-2-initiated de-coordination and thereafter aggregation of the AIE-S complex.
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