Journal
THERANOSTICS
Volume 4, Issue 6, Pages 614-628Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.8478
Keywords
Nanoparticles; photodynamic therapy; Positron Imaging Tomography; Reactive Oxygen species
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Funding
- NIH [RO1 CA127369]
- RPCI Support Grant [P30CA16056]
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In this report we demonstrate the outstanding advantages of multifunctional nanoplatforms for cancer-imaging and therapy. The non-toxic polyacrylamide (PAA) nanoparticles (size: 18-25 nm) formulation drastically changed the pharmacokinetic profile of the I-124-labeled chlorophyll-a derivative (formulated in 10% ethanol in PBS) with a remarkable enhancement in tumor uptake, and significantly reduced uptake in spleen and liver. Among the various nanoformulations investigated, the I-124-labeled photosensitizer (dose: 0.6142 MBq), and the cyanine dye-nanoparticles (CD-NP) conjugate (dose 0.3 mu mol/kg) in combination showed great potential for tumor imaging (PET/NIR fluorescence) in BALB/c mice bearing Colon26 tumors. Compared to free non-labeled photosensitizer, the corresponding PAA nanoformulation under similar treatment parameters showed a remarkable enhancement in long-term tumor cure by PDT (photodynamic therapy) and provides an opportunity to develop a single nanoplatform for tumor-imaging (PET/fluorescence) and phototherapy, a practical See and Treat approach.
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