Journal
THERANOSTICS
Volume 3, Issue 9, Pages 633-649Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.6630
Keywords
gold nanostar; tumor-targeting; RGD receptor; near infrared imaging; photo-thermal therapy
Categories
Funding
- Natural Science Foundation Committee of China [NSFC 81000666, 81220108012, 81211140243, 81171395]
- Program for New Century Excellent Talents (NCET) in University of the Ministry of Education of China
- Priority Academic Program Development of Jiangsu Higher Education Institutions
Ask authors/readers for more resources
Uniform gold nanostars (Au NS) were conjugated with cyclic RGD (cRGD) and near infrared (NIR) fluorescence probe (MPA) or anti-cancer drug (DOX) to obtain multi-functional nano-constructs, Au-cRGD-MPA and Au-cRGD-DOX respectively. The NIR contrast agent Au-cRGD-MPA was shown to have low cytotoxicity. Using tumor cells and tumor bearing mice, these imaging nanoparticles demonstrated favorable tumor-targeting capability mediated by RGD peptide binding to its over-expressed receptor on the tumor cells. The multi-therapeutic analogue, Au-cRGD-DOX, integrates targeting tumor, chemotherapy and photo-thermotherapy into a single system. The synergistic effect of photo-thermal therapy and chemotherapy was demonstrated in different tumor cell lines and in vivo using S180 tumor-bearing mouse models. The viability of MDA-MB-231 cells was only 40 % after incubation with Au-cRGD-DOX and irradiation with NIR light. Both tail vein and intratumoral injections showed Au-cRGD-DOX treated mice exhibiting the slowest tumor increase. These results indicate that the multifunctional nanoconstruct is a promising combined therapeutic agent for tumor-targeting treatment, with the potential to enhance the anti-cancer treatment outcomes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available