Journal
THERANOSTICS
Volume 3, Issue 9, Pages 650-657Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.6668
Keywords
Silica nanoparticles; Drug delivery; Integrin alpha(v)beta(3); Bioimaging; Doxorubicin
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Funding
- NIH [5R00CA153772, RR005351/GM103390]
- Philbrook scholarship
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We report herein a straightforward and label-free approach to prepare luminescent mesoporous silica nanoparticles. We found that calcination at 400 degrees C can grant mesoporous organosilica nanoparticles with strong fluorescence of great photo-and chemical stability. The luminescence is found to originate from the carbon dots generated from the calcination, rather than the defects in the silica matrix as was believed previously. The calcination does not impact the particles' abilities to load drugs and conjugate to biomolecules. In a proof-of-concept study, we demonstrated that doxorubicin (Dox) can be efficiently encapsulated into these fluorescent mesoporous silica nanoparticles. After coupled to c(RGDyK), the nanoconjugates can efficiently home to tumors through interactions with integrin alpha(v)beta(3) overexpressed on the tumor vasculature. This calcination-induced luminescence is expected to find wide applications in silica-based drug delivery, nanoparticle coating, and immunofluorescence imaging.
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