Journal
THERANOSTICS
Volume 3, Issue 12, Pages 919-931Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.7026
Keywords
miRNA therapy; novel therapeutics; Neurodegenerative disorders; Cardio-vascular diseases and metabolic disorders
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Funding
- LKC School of Medicine, NTU Singapore
- A*STAR (Agency for Science, Technology and Research), Singapore, Science Engineering Research Council (SERC) Biomedical Engineering Program (BEP) [103 149 0011]
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MicroRNAs (miRNAs), an abundant class of similar to 22-nucleotide non-coding RNAs, regulate the expression of genes at post transcriptional level. MiRNAs are important regulators of eukaryotic gene expression and therefore implicated in a wide range of biological processes. The miRNA-related genetic alterations are possibly more implicated human diseases than currently appreciated. Genetic variants in miRNA target sites, called miRNA genes are identified to be associated with human diseases. This review discusses about the role of micro-RNA genes in various human diseases such as neurodegenerative disorders, cardio-vascular diseases, and metabolic disorders, and how they can be targeted as a new therapeutic tool in future with reference to drug discoveries/development.
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