Journal
THERANOSTICS
Volume 2, Issue 3, Pages 251-257Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.3726
Keywords
carbon nanotube; thin film; virus detection; electrochemical impedance sensor; microelectrodes; M13-pIII antibody; M13 bacteriophage; ELISA
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Funding
- Natural Sciences and Engineering Research Council (NSERC) of Canada
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Here, we report the label-free, sensitive, and real-time electrical detection of whole viruses using carbon nanotube thin film (CNT-TF) field effect devices. Selective detection of approximately 550 model viruses, M13-bacteriophage, is demonstrated using a simple two-terminal (no gate electrode) configuration. Chemical gating through specific antibody-virus binding on CNT surface is proposed to be the sensing mechanism. Compared to electrical impedance sensors with identical microelectrode dimensions (no CNT), the CNT-TF sensors exhibit sensitivity 5 orders higher. We believe the reported approach could lead to a reproducible and cost-effective solution for rapid viral identification.
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